A major health insurance company
47. A major health insurance company is considering nationwide implementation of a test using biomarkers to screen for colon cancer. The test is delivered in health clinics in two similar regions of the country, with the following results:
|Region A||Region B|
What is the most likely cause of the difference in the test’s sensitivity and specificity between the two regions?
a. The prevalence of disease is different between the two regions
b. The test is detecting the disease earlier in its natural history in one of the regions.
c. length-biased sampling has occurred.
d. The test was not administered in similar conditions in the two regions
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