Why might depth-of-coverage histograms deviate

Why might depth-of-coverage histograms deviate

Flag question: Question 5

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Question 5 1 pts

Why might depth-of-coverage histograms deviate from expected theoretical distributions?

Group of answer choices

 

SNPs and other polymorphims

 

Repeated sequences and extremes of GC content (i.e. unusually high and low %GC)

 

High coverage is repeats, missing coverage is unknown

 

None of the above

 

Flag question: Question 6

Question 6 1 pts

What factors may lead to missing SNPs at low coverage?

Group of answer choices

 

Cannot discriminate SNP bases from read errors

 

Insufficient sampling of the “other”, non-reference-sequence allele

 

May miss SNP location due to low sampling

 

All of the above

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